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FALANGA GIORGIA
FALANGA GIORGIA
Ruolo:
Dottorando/a
Struttura di afferenza: CLASSE STS

Biografia

I graduated in Biotechnology and Medical Biology from Università Vita-Salute San Raffaele in Milan. During my academic training, I developed a strong interest in molecular and cellular mechanisms underlying neurological disorders. I gained hands-on experience in experimental research through my internship in the Protein Signaling in Brain Pathology and Physiology laboratory, where I worked with zebrafish models and applied molecular biology techniques.

My training provided me with solid expertise in gene expression analysis, cloning strategies, and functional assays to investigate signaling pathways involved in neurodevelopment and neurodegeneration. I am particularly motivated by translational research approaches that bridge basic molecular biology with clinical neuroscience. I am a highly organized and analytical researcher, with strong critical thinking skills and a deep interest in understanding disease mechanisms at the cellular level. 

Now I start my Phd program working on identifying the key regulators that control the timing of neuronal maturation in the central nervous system. My research focuses on deciphering molecular and epigenetic networks that govern the progressive acquisition of neuronal phenotypes, including morphology, excitability, synaptic function, and metabolic shifts. I aim to understand the regulatory logic underlying the temporal coordination of these maturation processes. I use human pluripotent stem cell (hPSC)-based differentiation systems to model region-specific neuronal development.A central goal is to investigate why different neuron types and brain regions mature at distinct rates.I analyze both shared and cell-type-specific molecular programs that determine temporal scaling across neuron populations. I seek to identify upstream regulators capable of accelerating, delaying, or potentially reverting aspects of neuronal maturation. I would like to develop experimental platforms that allow precise control of developmental stage both in vitro and after transplantation in vivo.These approaches enable high-resolution mapping of how genetic and environmental risk factors impact maturation trajectories. Overall, my work aims to understand and manipulate neuronal maturation timing to improve developmental and disease models.